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Synonyms for granulosis rubra nasi are: a peculiar form of acne with changes in the sweat glands (Luithlen); perisyringitis chronica nasi (Jadassohn); dermatiti. Granulosis rubra nasi is a rare disorder of the eccrine glands, inherited as an autosomal dominant trait. It is clinically characterized by hyperhidrosis of the  ‎Abstract · ‎INTRODUCTION · ‎CASE REPORT · ‎DISCUSSION. Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose.


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GRN usually resolves at puberty; however, rarely it may persist in adulthood.

We here report a case of GRN having lesions persisting in adulthood. Moreover, she showed excellent response to topical tacrolimus, a finding not observed in literature. Granulosis rubra nasi, GRN, eccrine sweat granulosis rubra nasi, face, hyperhidrosis.

Granulosis rubra nasi

Introduction Granulosis rubra nasi GRN is an inflammatory condition involving eccrine sweat glands of central face and clinically granulosis rubra nasi as erythema, hyperhidrosis, papules, pustules and vesicles over central face.

It runs a chronic course and resolves at puberty without any sequale. Case Report A 20 years-old girl granulosis rubra nasi with multiple discrete asymptomatic reddish vesicles over cheeks, nose, and forehead for four years Figure 1.

She had first noticed redness and increased sweating over central face 10 years back.


Any image downloaded must only be used for teaching purposes and not for commercial use. Biopsy findings supported the diagnosis of granulosis rubra nasi.


This case is being reported for its rarity since to the best of our knowledge, it has granulosis rubra nasi been reported in Indian subjects so far. As a result of persistent hyperhidrosis, diffuse erythema develops over the tip of the nose.

Case Reports in Dermatological Medicine

Erythema may gradually extend to involve upper lip, cheeks, and chin with sweat droplets studded over, giving glistening appearance.

Small erythematous macules, papules, vesicles, or pustules lesions can also be seen granulosis rubra nasi 28 ]. These lesions disappear on diascopy and reappear on relieving pressure [ 2 ].

The pathogenesis is unknown. It granulosis rubra nasi an inflammatory dermatosis involving eccrine sweat glands of central face involving nose, cheeks, or chin, representing a unique sweat retention form [ 2 ].

Granulosis Rubra Nasi Response to Topical Tacrolimus

Some authors have suggested a defect in vasomotor and secretory functions of the nose. Presence granulosis rubra nasi significant increase in sweating on the nose and central face appears to be responsible for the secondary changes like erythema and erythematous papules [ 9 ].

The differential diagnosis like rosacea or perioral dermatitis can be considered. But, in rosacea, there is erythema over nose and cheeks along with telangiectasias but there is no hyperhidrosis of the central part of the face.

Perioral dermatitis can present with erythema, small monomorphic papules, and pustules with or without scaling granulosis rubra nasi the perioral area without hyperhidrosis.

Granulosis rubra nasi

Other differential diagnoses include acne vulgaris, lupus pernio, lupus erythematosus, lupus vulgaris, leishmaniasis, actinic keratosis granulosis rubra nasi skin cancer, miliaria crystallina, and hidrocystoma [ 2410 ].

Acne vulgaris presents with granulosis rubra nasi, papules, and pustules without hyperhidrosis and telangiectasia. Lupus pernio or chilblain lupus presents with dusky papules and plaques on the nose, toes, and fingers.

Lupus erythematosus has history of photosensitivity. In acute lupus erythematosus, there is a malar rash with mouth ulcers but there is no hyperhidrosis.

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  • Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus
  • Granulosis Rubra Nasi Response to Topical Tacrolimus